Therapist Unlimited Blog

According to a latest medical study African Americans have more chances to suffer from hypertension and kidney disease than white Americans.
Based on the study conducted by the Physician-scientists from NewYork-Presbyterian Hospital/Weill Cornell Medical Center it was believed that a heightened level a certain growth factor in the blood may explain explained why blacks have a greater prevalence of hypertension and kidney disease compared to whites.
Recent medical statistics from the National Institutes of Health’s U.S. Renal Data System it was shown that African Americans constitute about 32 percent of all patients treated for kidney failure in the U.S. and are four times more likely to develop renal disease than whites.
With their discovery, researchers hoped that someday their study will lead to the development of a new class of anti-hypertensive and kidney disease drugs that target the TGF-b1 protein Dr. Manikkam Suthanthiran, first author of the study and attending physician at NewYork-Presbyterian/Weill Cornell explained he believe their study is a took for the world to understand the great puzzle: why the black population has a greater prevalence of hypertension and kidney disease.

African Americans need to be vigilant at all times since they are at higher risk of hypertension and kidney disease than the white Americans.

Suthanthiran revealed after controlling for race, sex and age, TGF-b1 protein levels were highest in hypertensive blacks (46 ng/ml).
Non-hypertensive blacks also had higher levels (42 ng/ml) compared to hypertensive whites (40 ng/ml) and non-hypertensive whites (39 ng/ml), demonstrating that even healthy black patients may be at higher risk for future hypertension and renal disease compared to healthy and hypertensive whites.
Moreover, Suthanthiran and his team revealed many black patients may have a disadvantage from the start having a higher baseline level of TGF-b1.
Dr. Phyllis August, senior author and attending physician in the division of hypertension at NewYork-Presbyterian Hospital/Weill Cornell Medical Center for his part said while the exact mechanisms of TGF-b1 require further study, he believe that in black patients, higher levels of the growth factor are correlated with lower renin activity an enzyme that constricts blood vessels and raises blood pressure.
It is said that high blood pressure is the leading risk factor for end-stage kidney disease.
The researchers perceive it may be possible that higher levels of TGF-b1 boost retention of sodium salt within the kidneys, leading to higher blood pressure in the kidney and also lower levels of renin.
The researchers also concluded greater levels of TGF-b1 in blacks were also positively associated with body mass index (BMI) an indicator of body fatness compared to height and metabolic syndrome, a group of abnormalities that is associated with atherosclerotic vascular disease and diabetes.
They believe future clinical studies must be done so we may fully understand the specific role of TGF-b1 in how the kidney handles sodium, blood pressure and kidney disease.