Therapist Unlimited Blog

A recent study done in Japan has shown that cancer can be transferred from mother to unborn child.
The study was the work of first author Takeshi Isoda from the Department of Pediatrics and Developmental Biology at Tokyo Medical and Dental University, and colleagues.
The researchers discovered that cases of mother to offspring transmission of cancer are rare and few have been recorded over the last 100 years, wrote the authors, and there is barely any evidence that shows the mother’s cancer cells match the baby’s.
In the paper, Isoda and colleagues describe a case where a 28-year old mother was diagnosed with leukemia shortly after giving birth to a baby girl who developed similar symptoms when she was nearly a year old.

 

 

 

 

Pregnant women should keep themselves healthy and away from cancer since they can transmit this deadly disease to their kids.

 

Using various methods, Isoda and colleagues were able to show that the cancer cells in the baby were a genetic match to those of the mother.
First they generated clones of the cancer cells from both mother and baby and found that they "shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin", and then they showed that "microsatellite markers in the infant cancer were all of maternal origin".
They also found that the baby’s cancer cells had inherited a pattern of missing genes (notably a "major deletion on one copy of chromosome 6p that included deletion of HLA alleles") that probably helped the cells avoid detection and destruction by the placental barrier and the baby’s immune system.