Those women, who survived cancer during their childhood, need to closely monitored since recent medical studies has shown that they are at higher risk of birth complications.
Dr. Sharon Lie Fong, of the Department of Obstetrics and Gynaecology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands and her colleagues get the data after studying the pregnancies of 40 women who had been treated for cancer during their childhood, the majority of them for leukaemia, but also for solid tumours.
Fong said from their subjects, six had had radiation treatment directly to the abdomen.
She said the data they gathered were compared with those from a control group of more than 9,000 women who had not had cancer treatment.
She added all data were obtained from The Netherlands Prenatal Register, a nationwide database of pregnancy outcomes.
The medical expert said data were matched for age at pregnancy, year and month of delivery, and the number of times the woman had given birth.
The medical expert added the team did not investigate overall fertility and miscarriage rates, but they believe that it is possible that the fertility of all the cancer survivors will be compromised.
Fong said the ovarian reserve or capacity of the ovary to provide eggs capable of fertilisation, is established in the foetus and decreases during a woman’s reproductive lifetime.
Women who survived cancer during their childhood need to be careful since they are at higher risk of birth complications.
Fong added women with a poor ovarian reserve are less likely to conceive, even with assisted reproduction therapies, than those with a normal number of eggs.
She said women might also have an earlier menopause, as their stock of eggs is exhausted at a younger age.
She revealed long-term, multi-disciplinary follow-up for female child cancer survivors is mandatory.
Furthermore, the researchers said although at the start of treatment, future fertility may not be of great concern to care providers; it is to the patient’s parents.
The researchers added during follow-up, survivors should be made aware of the possible late effects of their treatment.
They said in addition to the deleterious effects of abdominal radiotherapy on reproductive function, radiotherapy to the head can also cause problems by causing the hypothalamus to reduce the production of follicle stimulating hormone and luteinizing hormone, both important in promoting ovulation.
The team believe that it is particularly important for all female children who are treated for cancer, and their parents, to be made aware of this risk.
They said their research has also shown how important it is that, if they do become pregnant, childhood cancer survivors should be closely monitored throughout their pregnancy and that they are delivered in a clinical setting, rather than at home.
The researchers concluded that even if at first fertility seems normal for childhood cancer survivors, there may be problems later in life.
Pregnant women around the world better be careful since their babies would most likely suffer autism if they experience some complications during pregnancy.
Based on the study conducted by trusted researchers they discovered six pregnancy-related factors that could lead to autism on their children.
The researchers found that the factors most strongly associated with an increased autism risk are:
- Being born to an older mother or father.
- Having a mother who was born abroad.
- Having a mother who experienced bleeding during pregnancy.
- Having a mother who experienced gestational diabetes.
- Having a mother who used medication during pregnancy.
- Being the first born - or later born in families where there are three or more children.
The researchers explained increased maternal age might be associated with autism because of a higher risk of chromosomal abnormalities in eggs.
On the other hand, mothers who are born in another country may not have natural resistance to infections in the country where they give birth, which may increase the risk for autism.
Pregnant women should take precautions to avoid complications during pregnancy to avoid chances that their babies will suffer from autism.
Moving to another country may also put women under stress, which could increase their chances of having a child who develops autism.
Bleeding during pregnancy, gestational diabetes and medication use are also associated with increased autism risk. Bleeding can cause foetal hypoxia (lack of oxygen to the brain of an unborn child). Women who develop diabetes during pregnancy experience hormonal and metabolic changes, which may affect their baby’s health and development. Foetal development may also be affected by some medications, which can cross the placenta during pregnancy.
Furthermore, the researchers said the association between birth order and autism risk is unclear.
However, children with autism are more likely to be the first-born in families with only two children. In larger families with three or more children, they are more likely to be born later.
It is possible that parents decide not to have more children after one has developed autism.
The researchers said there was "insufficient evidence" to point to any one prenatal factor as being particularly significant.
However, they said there is some evidence to suggest that exposure to pregnancy complications in general may increase the risk of autism.