Therapist Unlimited Blog

Patients suffering from diabetes had reasons to be happy these days.
A recent medical study has shown that grapes had some substance that could help prevent and cure diabetes.
According to the research, a naturally produced molecule called resveratrol, found in the skin of red grapes, has been shown to lower insulin levels in mice when injected directly into the brain, even when the animals ate a high-fat diet.
The study s from a new UT Southwestern Medical Center study suggest that when acting directly on certain proteins in the brain, resveratrol may offer some protection against diabetes. Prior research has shown that the compound exerts anti-diabetic actions when given orally to animals with type 2 diabetes (non-insulin dependent diabetes mellitus), but it has been unclear which tissues in the body mediated these effects.
Dr. Roberto Coppari, assistant professor of internal medicine at UT Southwestern explained their research shows that the brain plays an important role in mediating resveratrol’s anti-diabetic actions, and it does so independent of changes in food intake and body weight.
Coppari added these animals were overrun with fat and many of their organs were inflamed.
He said  when we delivered resveratrol in the brain, it alleviated inflammation in the brain.
He revealed the main reason is that resveratrol does not cross the blood brain barrier efficiently.
"In order for the brain to accumulate the same dose of resveratrol delivered in our study, the amounts of red wine needed daily would surely cause deleterious effects,especially in the liver," Coppari said.
Coppari said their study points out that resveratrol’s analogs that selectively target the brain may help in the fight against diet-induced diabetes."

A latest medical study has shown that grapes could help prevent and cure diabetes.
 

For the study, the researchers investigated what happens when resveratrol acts only in the brain. Specifically, they wanted to know whether resveratrol injected in the brain activated a group of proteins called sirtuins, which are found throughout the body and thought to underlie many of the beneficial effects of calorie restriction. Previous animal research has shown that when these proteins are activated by resveratrol, diabetes is improved. In addition, drugs activating sirtuins currently are being tested as anti-diabetic medications in human trials, Coppari said.
In one group of animals, researchers injected resveratrol directly into the brain; another group received a saline-based placebo. All the surgically treated animals consumed a high-fat diet before and after the surgery.
Coppari said the insulin levels of the animals treated with the placebo solution rose increasingly higher post-surgery. "That’s a normal outcome because insulin sensitivity decreases the longer you keep an animal on a high-fat diet."
Insulin levels in the mice given resveratrol, however, actually started to drop and were halfway to normal by the end of the five-week study period, even though the animals remained on a high-fat diet.
In addition, the researchers found that resveratrol did indeed activate sirtuin proteins in the brain.
Coppari said the findings support his team’s theory that the brain plays a vital role in mediating the beneficial effects of resveratrol and that manipulation of brain sirtuins also may have other beneficial outcomes. "By knowing that the central nervous system is
involved, pharmaceutical companies can begin to focus on developing drugs that selectively target sirtuins in the brain," he said.
The next step, Coppari said, is to determine precisely which neurons in the brain are mediating the effects of the resveratrol.
Other UT Southwestern researchers involved in the study include Drs. Giorgio Ramadori, Laurent Gautron and Teppei Fujikawa, postdoctoral researchers in internal medicine; Dr. Claudia Vianna, instructor of internal medicine; and Dr. Joel Elmquist, professor of internal medicine and director of the Center for Hypothalamic Research at UT Southwestern.
The study was supported by the American Heart Association, National Institutes of Health and the American Diabetes Association.

Pregnant women around the world should avoid exposure to environmental pollutants known as polycyclic aromatic hydrocarbons (PAHs) since it can adversely affect a child’s intelligence quotient or IQ.
Based on the study conducted by the Columbia Center for Children’s Environmental Health (CCCEH) at the Mailman School of Public Health it was learned that PAHs are chemicals released into the air from the burning of coal, diesel, oil and gas, or other organic substances such as tobacco.
It is said that in urban areas motor vehicles are a major source of PAHs.
According to the study, funded by the National Institute of Environmental Health Sciences (NIEHS), a component of the National Institutes of Health, the U.S. Environmental Protection Agency and several private foundations, children exposed to high levels of PAHs in New York City had full scale and verbal IQ scores that were 4.31 and 4.67 points lower, respectively than those of less exposed children.
Researchers reveal high PAH levels were defined as above the median of 2.26 nanograms per cubic meter (ng/m3).
Frederica Perera, DrPH, professor of Environmental Health Sciences and director of the CCCEH at Columbia University Mailman School of Public Health and study lead author explained their findings are of concern because these decreases in IQ could be educationally meaningful in terms of school performance.
Perera added the good news is that they have seen a decline in air pollution exposure in our cohort since 1998, testifying to the importance of policies to reduce traffic congestion and other sources of fossil fuel combustion byproducts.
The study included children who were born to non-smoking Black and Dominican American women age 18 to 35 who resided in Washington Heights, Harlem or the South Bronx in New York.
The children were followed from in utero to 5 years of age.

Pregnant women around the world should avoid exposure to urban air pollutants to protect the IQ of their children.

The mothers wore personal air monitors during pregnancy to measure exposure to PAHs and they responded to questionnaires.
At 5 years of age, 249 children were given an intelligence test known as the Wechsler Preschool and Primary Scale of the Intelligence, which provides verbal, performance and full-scale IQ scores.
The researchers developed models to calculate the associations between prenatal PAH exposure and IQ.
The researchers added other factors such as second-hand smoke exposure, lead, mother’s education and the quality of the home caretaking environment could also affect the IQ of the baby.
The study has shown that participants exposed to air pollution levels below the average were designated as having "low exposure," while those exposed to pollution levels above the average were identified as "high exposure."
A total of 140 children were classified as having high PAH exposure.
Furthermore, Perera said the decrease in full-scale IQ score among the more exposed children is similar to that seen with low-level lead exposure.
Perera added this finding is of concern because IQ is an important predictor of future academic performance, and PAHs are widespread in urban environments and throughout the world.
She said fortunately, airborne PAH concentrations can be reduced through currently available controls, alternative energy sources and policy interventions.

Those people who have no job are most likely to get sick as well.
This was the observation of a group of researchers based in Australia.
According to the result of their study, there is a clear connection between unemployment and health.
The data gathered by researchers also shows a direct relationship between poor health and earning potential.
With their findings, the researchers hoped that the government will add more money in the health programs to help those who are unemployed.
 Dr. Andrew Pesce, the head of the researchers then renewed calls for the governments to invest in health as a national priority.
Pesce said their research highlighted the impact unemployment has on health underlining the debilitating stress and emotional impacts experienced by individuals and communities in tough economic times.

Pesce added the research also shows the other side of that coin that ill health prevents people from contributing to the economy
He said their research is a further proof that investing in health not only contributes to longer, happier and healthier lives, but that investment has a direct and lasting impact on the productivity of the workforce.
He added the report’s finding, that the financial consequences of ill health are ‘clearly great’, comes as no surprise to the medical profession, citing that they have long been urging the government to include health in stimulus investment, but to no avail.
Furthermore, Pesce hoped the piece of evidence they gather will convince governments that there is no better investment than health.
 

Men around the world should take many antioxidants since low doses of such kind of chemical compound could affect the quality of their semen.
According to the report posted on the online journal Fertility and Sterility it was discovered that low antioxidant intake is associated with low reproductive capacity in semen.
The researchers lead by Jaime Mendiola said their study has shown that men who eat large amounts of meat and full fat dairy products have lower seminal quality than those who eat more fruit, vegetables and reduced fat dairy products.
Mendiola revealed those men who ate many fruits and vegetables are ingesting more antioxidants, which is why their sperm quality is good.
Mendiola said he and his team have allocated four years of their time examining the link between dietary habits or workplace exposure to contaminants and the quality of semen among men attending fertility clinics.

The male population around the world should eat more fruits and vegetables to ensure they have sufficient antioxidants in their body to keep their semen quality healthy.

He explained their objective was to find out whether a higher or lower intake of vitamins, which act as antioxidants, could affect semen quality.
Moreover, the lead researcher said molecules, which are present in foods such as citrus fruits, peppers and spinach, work by lowering the level of oxidative stress that can affect semen quality, and improve sperm concentration parameters as well as sperm mobility and morphology.
The lead researcher said the study was carried out among 61 men, 30 of whom had reproductive problems, while the remaining 31 acted as controls.
He said a healthy diet is not only a good way of avoiding illness, but could also have an impact on improving seminal quality.